A selective agonist of S1P3
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CYM 5541

Item No. 15190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
CAS Number
945128-26-7
Synonyms
  • CID-17253208
  • ML-249
Molecular Formula
C19H28N2O2
Formula Weight
316.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
232 nm
SMILES
O=C(N(C1CCCCC1)C2CCCCC2)C3=NOC(C4CC4)=C3
InChi Code
InChI=1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
InChi Key
NDKGACIWVAOUQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $233

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    50 mg

    $427

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    Product Description

    CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM).1,2 It less effectively activates S1P1 (EC50 = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., et al. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3). 1-13 (2011).

    2. Jo, E., Bhhatarai, B., Repetto, E., et al. Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem. Biol. 7(12), 1975-1983 (2012).