A potent and selective inhibitor of Kv7.2 channels
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ML-252 (hydrochloride)

Item No. 15191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide, monohydrochloride
CAS Number
2309887-61-2
Molecular Formula
C20H24N2O • HCl
Formula Weight
344.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
257, 304 nm
SMILES
CC[C@H](C(NC1=CC=CC=C1N2CCCC2)=O)C3=CC=CC=C3.Cl
InChi Code
InChI=1S/C20H24N2O.ClH/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22;/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23);1H/t17-;/m0./s1
InChi Key
XBYCQOZNTLUEDX-LMOVPXPDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $236

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    Product Description

    ML-252 is a potent and selective inhibitor of the voltage-gated potassium channel subtype Kv7.2 (IC50 = 69 nM in a patch clamp assay).1 It is the (S)-enantiomer and is more potent than the (R)-enantiomer and the racemic mixture (IC50s = 944 and 160 nM, respectively). It is selective for Kv7.2 over other Kv channel subtypes, >68 G protein-coupled receptors, transporters, L- and N-type calcium channels, and KATP and hERG potassium channels though it does inhibit the melatonin MT1 receptor 61% when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheung, Y.-Y., Yu, H., Xu, K., et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of Kv7.2 (KCNQ2) channel pharmacology: Identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant Kv7.2 channel inhibitor. J. Med. Chem. 55(15), 6975-6979 (2012).