An agonist of μ-opioid and δ-opioid receptor heterodimerization
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ML-335

Item No. 15196

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-4-piperidinecarboxylic acid, ethyl ester
CAS Number
1069498-96-9
Synonyms
  • CID-23723457
  • CYM 51010
Molecular Formula
C25H32N2O3
Formula Weight
408.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
249 nm
SMILES
CC(NC(C=C1)=CC=C1CN2CCC(C(OCC)=O)(CCC3=CC=CC=C3)CC2)=O
InChi Code
InChI=1S/C25H32N2O3/c1-3-30-24(29)25(14-13-21-7-5-4-6-8-21)15-17-27(18-16-25)19-22-9-11-23(12-10-22)26-20(2)28/h4-12H,3,13-19H2,1-2H3,(H,26,28)
InChi Key
VUXRYYSKTWDPLO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    ML-335 is the first identified agonist for OPRM1-OPRD1 heterodimerization (EC50 = 403 nM) that demonstrates selectivity over the individual OPRM1 and OPRD1 receptors and the serotonin HT5A receptor (EC50s = 14.9, 1.1, and >40 μM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinello, C., Guerrero, M., Eberhart, C., et al. Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization. Probe Reports from the NIH Molecular Libraries Program 1-14 (2012).