An inhibitor of kynurenine 3-hydroxylase
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Ro 61-8048

Item No. 15199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide
CAS Number
199666-03-0
Molecular Formula
C17H15N3O6S2
Formula Weight
421.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 14 mg/mlEthanol: 0.5 mg/ml
λmax
210, 249, 278 nm
SMILES
O=S(NC1=NC(C2=CC([N+]([O-])=O)=CC=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O
InChi Code
InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
InChi Key
NDPBMCKQJOZAQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $124

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    25 mg

    $284

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    50 mg

    $392

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    Product Description

    Ro 61-8048 is a potent inhibitor of kynurenine 3-hydroxylase (IC50 = 37 nM), preventing the conversion of kynurenine (Item No. 11305) to 3-hydroxy kynurenine.1 Ro 61-8048 inhibition of kynurenine 3-hydroxylase reduces ischemia-mediated neuronal damage in tissues.1,2 Ro 61-8048 can be used in vivo by direct injection.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Röver, S., Cesura, A.M., Huguenin, P., et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J. Med. Chem. 40(26), 4378-4385 (1997).

    2. Carpenedo, R., Meli, E., Peruginelli, F., et al. Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures. J. Neurochem. 82(6), 1465-1471 (2002).

    3. Hamann, M., Sander, S.E., and Richter, A. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dtsz mutant. Eur. J. Pharmacol. 586(1-3), 156-159 (2008).