A tool for ablating zebrafish larval melanocytes
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Stem Cell Research
Proliferation

MoTP

Item No. 15204

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-(4-morpholinyl)butyl]thio]-phenol
CAS Number
57055-82-0
Synonyms
  • 4-(4-Morpholinylbutylthio)phenol
Molecular Formula
C14H21NO2S
Formula Weight
267.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 25 mg/mlEthanol: 0.3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
229, 257 nm
SMILES
OC1=CC=C(SCCCCN2CCOCC2)C=C1
InChi Code
InChI=1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2
InChi Key
YHKNLUTUXZDOQI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $153

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    25 mg

    $294

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    Product Description

    MoTP, known more formally as 4-(4-morpholinobutylthio)phenol, is used to ablate larval melanocytes in zebrafish in order to study melanocyte regeneration.1,2 MoTP is converted to a cytotoxin in cells with high tyrosinase activity, which in the zebrafish embryo are limited to melanoblasts and newly formed melanocytes.3 The wash-out of MoTP allows regeneration through the proliferation of melanocyte stem cells.3,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, C.T., and Johnson, S.L. Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes. Development 133(18), 3563-3573 (2006).

    2. Yang, C.T., Hindes, A.E., Hultman, K.A., et al. Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish. PLoS Genetics 3(6), e88 (2007).

    3. Hultman, K.A., Budi, E.H., Teasley, D.C., et al. Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genetics 5(7), e1000544 (2009).