A potent inhibitor of the TRPA1 channel
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A-967079

Item No. 15207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime
CAS Number
1170613-55-4
Molecular Formula
C12H14FNO
Formula Weight
207.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 20 mg/ml
λmax
267 nm
SMILES
FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1
InChi Code
InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
InChi Key
HKROEBDHHKMNBZ-CHBKHGQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $72

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $556

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    Product Description

    A-967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.1 It attenuates cold allodynia following nerve injury without producing locomotor or cardiovascular side effects.1 A-967079 also suppresses neuronal activity in response to mechanical stimulation and diminishes postoperative pain due to mechanical stimuli.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Joshi, S.K., DiDomenico, S., et al. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152(5), 1165-1172 (2011).

    2. McGaraughty, S., Chu, K.L., Perner, R.J., et al. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol. Pain 6, 14 (2010).

    3. Wei, H., Karimaa, M., Korjamo, T., et al. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117(1), 137-148 (2012).