An activator of cardiac differentiation
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Shz-1

Item No. 15211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenesulfonic acid, 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
CAS Number
326886-05-9
Synonyms
  • Sulfonylhydrazone-1
Molecular Formula
C13H11BrN2O3S
Formula Weight
355.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
219, 275, 329 nm
SMILES
O=S(C1=CC=CC=C1)(N/N=C/C2=C(O)C=CC(Br)=C2)=O
InChi Code
InChI=1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+
InChi Key
OEMCLQLAWYKPRK-OQLLNIDSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $118

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    10 mg

    $159

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    50 mg

    $655

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    Product Description

    Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.1 In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating factor, toward a cardiac phenotype.1 These Shz-1 treated cells enhance myocardial regenerative repair in cryo-injured rat heart.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sadek, H., Hannack, B., Choe, E., et al. Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc. Natl. Acad. Sci. USA 105(16), 6063-6068 (2008).