An irreversible inhibitor of glucocerebrosidase
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Conduritol B epoxide

Item No. 15216

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-anhydro-myo-inositol
CAS Number
6090-95-5
Synonyms
  • CBE
Molecular Formula
C6H10O5
Formula Weight
162.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H]2[C@@H]1O2
InChi Code
InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1
InChi Key
ZHMWOVGZCINIHW-FTYOSCRSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $60

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    25 mg

    $171

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    50 mg

    $283

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    Product Description

    Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 μM).1,2 Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes.3 It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.4 As glucocerebrosidase deficiency results in Gaucher disease, a common lysosomal storage disorder that can involve defects in blood, bone, neurological, and liver development, CBE is used in in vitro and animal models of the disease.2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ogawa, S., Uetsuki, S., Tezuka, Y., et al. Synthesis and evaluation of glucocerebrosidase inhibitory activity of anhydro deoxyinositols from (+)-epi- and (−)-vibo-quercitols. Bioorg. Med. Chem. Lett. 9(11), 1493-1498 (1999).

    2. Witte, M.D., Kallemeijn, W.W., Aten, J., et al. Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nat. Chem. Biol. 6(12), 907-913 (2010).

    3. Newburg, D.S., Yatziv, S., McCluer, R.H., et al. β-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: An in vitro model of the Gaucher cell. Biochim. Biophys. Acta 877(1), 121-126 (1996).

    4. Ishibashi, Y., Kohyama-Koganeya, A., and Hirabayashi, Y. New insights on glucosylated lipids: metabolism and functions. Biochim. Biophys. Acta 1831(9), 1475-1485 (2013).