A Hedgehog pathway inhibitor
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HPI-1 (hydrate)

Item No. 15221

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid-2-methoxyethyl ester, hydrate
Molecular Formula
C27H29NO6 • XH2O
Formula Weight
463.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 3 mg/mlEthanol: 20 mg/ml
SMILES
COC1=CC=CC=C1C2CC(NC(C)=C(C(OCCOC)=O)C3C4=CC(O)=CC=C4)=C3C(C2)=O.O
InChi Code
InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
InChi Key
BOASXIAGFOONSK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $117

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    10 mg

    $206

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    25 mg

    $484

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    50 mg

    $853

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    Product Description

    HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 ≥ 30 µM).1 HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1 HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyman, J.M., Firestone, A.J., Heine, V.M., et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc. Natl. Acad. Sci. USA 106(33), 14132-14137 (2009).