An HCN channel blocker
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ZD 7288

Item No. 15228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride
CAS Number
133059-99-1
Synonyms
  • ICI-D 7288
Molecular Formula
C15H21N4 • Cl
Formula Weight
292.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
241, 285 nm
SMILES
CCN(C1=NC(C)=[N+](C)C(NC)=C1)C2=CC=CC=C2.[Cl-]
InChi Code
InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChi Key
DUWKUHWHTPRMAP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $209

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    50 mg

    $377

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    100 mg

    $586

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    500 mg

    $1,463

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    Product Description

    ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).1 Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.2,3 In addition, ZD 7288 reduces neuropathic pain in several animal models.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McClure, K.J., Maher, M., Wu, N., et al. Discovery of a novel series of selective HCN1 blockers. Bioorg. Med. Chem. Lett. 21, 5197-5201 (2011).

    2. BoSmith, R.E., Briggs, I., and Sturgess, N.C. Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br. J. Pharmacol. 110(1), 343-349 (1993).

    3. Rouse, W., and Johnson, I.R. Haemodynamic actions of a novel sino-atrial node function modulator, ZENECA ZD7288, in the anaesthetized dog: A comparison with zatebradine, atenolol and nitrendipine. Br. J. Pharmacol. 113(3), 1064-1070 (1994).

    4. Luo, L., Chang, L., Brown, S.M., et al. Role of peripheral hyperpolarization-activated cyclic nucleotidemodulated channel pacemaker channels in acute and chronic pain models in the rat. Neuroscience 144, 1477-1485 (2007).

    5. Chen, Y., Lin, C., Tang, Y., et al. ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J. Gastroenterol. 20(8), 2091-2097 (2014).