A COX product of EPA
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Δ17-6-keto Prostaglandin F1α

Item No. 15230

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-oxo-9α,11α,15S-trihydroxy-prosta-13E,17Z-dien-1-oic acid
CAS Number
68324-95-8
Synonyms
  • ω-3 6-keto PGF2α
Molecular Formula
C20H32O6
Formula Weight
368.5
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/ml (from PGF1a)DMSO: >50 mg/ml (from PGF1a)Ethanol: >75 mg/ml (from PGF1a)PBS pH 7.2: >2.1 mg/ml (from PGF1a)
SMILES
O[C@@H]1[C@H](CC(CCCCC(O)=O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)[C@H](O)C1
InChi Code
InChI=1S/C20H32O6/c1-2-3-4-7-14(21)10-11-16-17(19(24)13-18(16)23)12-15(22)8-5-6-9-20(25)26/h3-4,10-11,14,16-19,21,23-24H,2,5-9,12-13H2,1H3,(H,25,26)/b4-3-,11-10+/t14-,16+,17+,18+,19-/m0/s1
InChi Key
HFKNJQYMAGMXTR-CAPHXMBKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

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    Product Description

    Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.1,2 Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J. Ocul. Pharmacol. 3(4), 349-356 (1987).

    2. Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31(6), 1159-1164 (1986).