A potent inhibitor of Porcupine
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IWP-L6

Item No. 15243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
CAS Number
1427782-89-5
Synonyms
  • PORCN Inhibitor III
  • Wnt Pathway Inhibitor XIX
Molecular Formula
C25H20N4O2S2
Formula Weight
472.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 2 mg/ml
λmax
269, 340 nm
SMILES
O=C1C2=C(CCS2)N=C(SCC(NC3=NC=C(C4=CC=CC=C4)C=C3)=O)N1C5=CC=CC=C5
InChi Code
InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
InChi Key
QESQGTFWEQMCMH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $169

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    50 mg

    $618

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    Product Description

    IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).1 It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.1 In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.1 It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Moon, J., Dodge, M.E., et al. The development of highly potent inhibitors for porcupine. J. Med. Chem. 56(6), 2700-2704 (2013).