A TRPM4 inhibitor
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9-Phenanthrol

Item No. 15248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
484-17-3
Synonyms
  • 9-Hydroxyphenanthrene
  • NSC 50554
Molecular Formula
C14H10O
Formula Weight
194.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
249, 254 nm
SMILES
OC1=CC2=C(C3=C1C=CC=C3)C=CC=C2
InChi Code
InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChi Key
DZKIUEHLEXLYKM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $54

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    100 mg

    $102

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    250 mg

    $238

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    500 mg

    $418

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    Product Description

    9-Phenanthrol is an inhibitor of transient receptor potential melastatin 4 (TRPM4; IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor).1 It is selective for TRPM4 over TRPM5 at 100 µM. 9-Phenanthrol (100 µM) reduces heart rate in spontaneously beating isolated mouse right atria.2 It reduces infarct size and apoptosis in isolated rat hearts in an ex vivo model of ischemia-reperfusion injury.3 In vivo, 9-phenanthrol reduces myogenic tone in rat cerebral arteries.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grand, T., Demion, M., Norez, C., et al. 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br. J. Pharmacol. 153(8), 1697-1705 (2008).

    2. Hof, T., Simard, C., Rouet, R., et al. Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm. Heart Rhythm 10(11), 1683-1689 (2013).

    3. Wang, J., Takahashi, K., Piao, H., et al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One 8(7), e70587 (2013).

    4. Gong, Y., Du, M.-Y., Yu, H.-L., et al. Increased TRPM4 activity in cerebral artery myocytes contributes to cerebral blood flow reduction after subarachnoid hemorrhage in rats. Neurotherapeutics 16(3), 901-911 (2019).