An inhibitor of the Arp2/3 complex
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CK-869

Item No. 15251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
CAS Number
388592-44-7
Synonyms
  • CK-0157869
Molecular Formula
C17H16BrNO3S
Formula Weight
394.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1.5 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
λmax
278 nm
SMILES
O=C1N(C2=CC=C(OC)C=C2OC)C(C3=CC=CC(Br)=C3)SC1
InChi Code
InChI=1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
InChi Key
MVWNPZYLNLATCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $30

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    5 mg

    $75

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    10 mg

    $119

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    25 mg

    $224

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    Product Description

    CK-869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells.1 It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 µM.2 It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ilatovskaya, D.V., Chubinskiy-Nadexhdin, V., Pavlov, T.S., et al. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. Cell Tissue Res. 354(3), 783-792 (2013).

    2. Nolen, B.J., Tomasevic, N., Russell, A., et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460(7258), 1031-1034 (2009).

    3. Beckham, Y., Vasquez, R.J., Stricker, J., et al. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. PLOS one 9(6), e100943 (2014).