An MCT1 inhibitor
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α-Cyano-4-hydroxycinnamic Acid

Item No. 15254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-(4-hydroxyphenyl)-2-propenoic acid
CAS Number
28166-41-8
Synonyms
  • CHC
  • α-CHCA
  • NSC 173138
Molecular Formula
C10H7NO3
Formula Weight
189.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 100 µg/ml
λmax
242, 344 nm
SMILES
OC1=CC=C(/C=C(C(O)=O)\C#N)C=C1
InChi Code
InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChi Key
AFVLVVWMAFSXCK-VMPITWQZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $40

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    5 g

    $171

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    Product Description

    α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 = 1.5 μM).1 It is commonly used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Halestrap, A.P. The mitochondrial pyruvate carrier: Kinetics and specificity for substrates and inhibitors. Biochem. J. 148(1), 85-96 (1975).

    2. Watanabe, M., Terasawa, K., Kaneshiro, K., et al. Improvement of mass spectrometry analysis of glycoproteins by MALDI-MS using 3-aminoquinoline/α-cyano-4-hydroxycinnamic acid. Anal. Bioanal. Chem. 405(12), 4289-4293 (2013).

    3. Yang, H., Wan, D., Song, F., et al. α-Cyano-4-hydroxycinnamic acid, sinapinic acid, and ferulic acid as matrices and alkylating agents for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cysteine-containing peptides. Rapid Commun. Mass Spectrom. 27(12), 1410-1412 (2013).