A caspase inhibitor with low cytotoxicity
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Q-VD-OPH

Item No. 15260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid
CAS Number
1135695-98-5
Synonyms
  • Quinoline-Val-Asp-Difluorophenoxymethyl Ketone
Molecular Formula
C26H25F2N3O6
Formula Weight
513.5
Purity
≥95% (mixture of tautomers)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 10 mg/ml
λmax
238, 289 nm
SMILES
O=C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(COC1=C(F)C=CC=C1F)=O)=O)C2=NC3=CC=CC=C3C=C2
InChi Code
InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1
InChi Key
OOBJCYKITXPCNS-REWPJTCUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $371

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    Product Description

    Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM.1,2 It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No. 14463) and Boc-D-FMK (Item No. 16118).1,2 Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.3,4 This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caserta, T.M., Smith, A.N., Gultice, A.D., et al. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 8(4), 345-352 (2003).

    2. Kuzelová, K., Grebenová, D., and Brodská, B. Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes. J. Cell. Biochem. 112(11), 3334-3342 (2011).

    3. Renolleau, S., Fau, S., Goyenvalle, C., et al. Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: A role for gender. J. Neurochem. 100(4), 1062-1071 (2007).

    4. Braun, J.S., Prass, K., Dirnagl, U., et al. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Exp. Neurol. 206(2), 183-191 (2007).

    5. Chen-Deutsch, X., Kutner, A., Harrison, J.S., et al. The pan-caspase inhibitor QVD has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Leuk. Res. 36(7), 884-888 (2012).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).