A TRPC3 and TRPC6 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GSK 417651A

Item No. 15268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-methanone
CAS Number
736945-96-3
Molecular Formula
C20H19N3O2S
Formula Weight
365.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
271 nm
SMILES
O=C(C1=CSC(NC2=CC=C(OC)C=C2)=N1)N(C3)CCC4=C3C=CC=C4
InChi Code
InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
InChi Key
NTXBDULODNTCKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $37

    Add

    5 mg

    $118

    Add

    10 mg

    $198

    Add

    25 mg

    $404

    Add
    Product Description

    GSK 417651A is an inhibitor of transient receptor potential canonical 3 (TRPC3) and TRPC6 (IC50 = ~0.4 µM for both).1 It inhibits migration of isolated human fibroblastic valve interstitial cells into the wounded area in a scratch test assay when used at a concentration of 2 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, X., Lozinskaya, I., Costell, M., et al. Characterization of small molecule TRPC3 and TRPC6 agonist and antagonists. Biophys. J. 104(2), 454A (2013).

    2. Al-Shammari, H., Latif, N., Sarathchandra, P., et al. Expression and function of mechanosensitive ion channels in human valve interstitial cells. PLoS One 15(10), e0240532 (2020).