A specific inhibitor of Cdc42
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MLS-573151

Item No. 15269

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
CAS Number
10179-57-4
Molecular Formula
C21H19N3O2S
Formula Weight
377.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 20 mg/ml
λmax
233, 272, 358 nm
SMILES
NS(C(C=C1)=CC=C1N2C(C3=CC=CC=C3)CC(C4=CC=CC=C4)=N2)(=O)=O
InChi Code
InChI=1S/C21H19N3O2S/c22-27(25,26)19-13-11-18(12-14-19)24-21(17-9-5-2-6-10-17)15-20(23-24)16-7-3-1-4-8-16/h1-14,21H,15H2,(H2,22,25,26)
InChi Key
OPPCVEVPKHRJNY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $129

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    10 mg

    $222

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    25 mg

    $469

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    Product Description

    MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM).1 It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.1 It acts by blocking the binding of GTP to Cdc42.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Surviladze, Z., Waller, A., Wu, Y., et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J. Biomol. Screen. 15(1), 10-20 (2013).