A Nampt inhibitor
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STF-118804

Item No. 15283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-benzamide
CAS Number
894187-61-2
Molecular Formula
C25H23N3O4S
Formula Weight
461.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
222, 300 nm
SMILES
CC1=CC=C(S(CC2=C(C)OC(C3=CC=C(C(NCC4=CN=CC=C4)=O)C=C3)=N2)(=O)=O)C=C1
InChi Code
InChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29)
InChi Key
DLFCEZOMHBPDGI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $186

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    50 mg

    $753

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    Cayman Chemical
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    Product Description

    STF-118804 is a small molecule inhibitor of Nampt (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide.1 It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV4-11 cells.1 At 50 mg/kg for 20 days, STF-118804 has been shown to improve survival in an orthotopic xenotransplant model of high-risk ALL in mice.1 It has also been shown to target leukemia stem cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matheny, C.J., Wei, M.C., Bassik, M.C., et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem. Biol. 20, 1352-1363 (2013).