An inhibitor of HIF-PH enzymes
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Isomer(s)
11573IOX2
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Product Type

Biochemicals

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Application

Roxadustat

Item No. 15294

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine
CAS Number
808118-40-3
Synonyms
  • ASP1517
  • FG-4592
Molecular Formula
C19H16N2O5
Formula Weight
352.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 0.1 mg/ml
λmax
223, 261, 314, 333 nm
SMILES
OC1=C(C(NCC(O)=O)=O)N=C(C)C2=C1C=CC(OC3=CC=CC=C3)=C2
InChi Code
InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
InChi Key
YOZBGTLTNGAVFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $28

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    25 mg

    $62

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    50 mg

    $104

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    100 mg

    $138

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    Product Description

    Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hsieh, M.M., Linde, N.S., Wynter, A., et al. HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaque. Blood 110(6), 2140-2147 (2007).

    Product Citations

    Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).

    Wu, D., Su, X., Lu, J., et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol. 15(4), 367-376 (2019).