A selective inhibitor of the ATPase p97
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DBeQ

Item No. 15318

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2,N4-bis(phenylmethyl)-2,4-quinazolinediamine
CAS Number
177355-84-9
Synonyms
  • N,N'-Dibenzylquinazoline-2,4-diamine
  • JRF 12
Molecular Formula
C22H20N4
Formula Weight
340.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 1.4 mg/ml
λmax
238, 281, 340 nm
SMILES
C12=CC=CC=C1N=C(NCC3=CC=CC=C3)N=C2NCC4=CC=CC=C4
InChi Code
InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChi Key
QAIMUUJJAJBPCL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM).1 It does not exhibit activity when tested against a panel of 170 protein kinases at concentrations as high as 15 μM.1 At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chou, T.F., Brown, S.J., Minond, D., et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. USA 108(12), 4834-4839 (2011).