A potent DPP-2 inhibitor
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UAMC-0039 (hydrochloride)

Item No. 15340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone, dihydrochloride
CAS Number
697797-51-6
Molecular Formula
C16H24ClN3O • 2HCl
Formula Weight
382.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 14 mg/mLEthanol: 5 mg/mLPBS (pH 7.2): 10 mg/mL
λmax
220 nm
SMILES
O=C([C@@H](N)CCNCC1=CC=C(Cl)C=C1)N2CCCCC2.Cl.Cl
InChi Code
InChI=1S/C16H24ClN3O.2ClH/c17-14-6-4-13(5-7-14)12-19-9-8-15(18)16(21)20-10-2-1-3-11-20;;/h4-7,15,19H,1-3,8-12,18H2;2*1H/t15-;;/m0../s1
InChi Key
IWXMOQGMIWZNPR-CKUXDGONSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $293

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    Product Description

    UAMC-0039 is a potent inhibitor of dipeptidyl peptidase 2 (DPP-2; IC50 = 0.48 nM).1 It also inhibits DPP-4 (IC50 = 165 µM). DPP-2 is thought to be involved in degradation of collagen, substance P, and some proline-containing neuropeptides.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Senten, K., Van der Veken, P., De Meester, I., et al. γ-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors. J. Med. Chem. 47(11), 2906-2916 (2004).

    2. Andersen, K.J., and McDonald, J.K. Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides. Ren. Physiol. Biochem. 12(1), 32-40 (1989).

    3. Mentlein, R., and Struckhoff, G. Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides. J. Neurochem. 52(4), 1284-1293 (1989).