An inhibitor of TrxR
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PMX-464

Item No. 15343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
CAS Number
485842-97-5
Synonyms
  • AW-464
Molecular Formula
C13H9NO2S
Formula Weight
243.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C=C1)C=CC1(O)C2=NC3=CC=CC=C3S2
InChi Code
InChI=1S/C13H9NO2S/c15-9-5-7-13(16,8-6-9)12-14-10-3-1-2-4-11(10)17-12/h1-8,16H
InChi Key
SDYBYKXWYDVVKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $65

    Add

    5 mg

    $195

    Add

    10 mg

    $325

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    PMX-464 is a quinol inhibitor of thioredoxin reductase (TrxR; mean IC50 = 6.5 µM for the rat enzyme).1 It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 0.23 µM). PMX-464 (30 µM) inhibits IL-1β-induced NF-κB DNA binding in A549 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chew, E.-H., Lu, J., Bradshaw, T.D., et al. Thioredoxin reductase inhibition by antitumor quinols: A quinol pharmacophore effect correlating to antiproliferative activity. FASEB J. 22(6), 2072-2083 (2008).

    2. Callister, M.E., Pinhu, L., Catley, M.C., et al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br. J. Pharmacol. 155(5), 661-672 (2008).