An inhibitor of TrxR
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PMX-464

Item No. 15343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
CAS Number
485842-97-5
Synonyms
  • AW-464
Molecular Formula
C13H9NO2S
Formula Weight
243.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C=C1)C=CC1(O)C2=NC3=CC=CC=C3S2
InChi Code
InChI=1S/C13H9NO2S/c15-9-5-7-13(16,8-6-9)12-14-10-3-1-2-4-11(10)17-12/h1-8,16H
InChi Key
SDYBYKXWYDVVKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $195

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    10 mg

    $325

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    Cayman Chemical
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    Product Description

    PMX-464 is a quinol inhibitor of thioredoxin reductase (TrxR; mean IC50 = 6.5 µM for the rat enzyme).1 It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 0.23 µM). PMX-464 (30 µM) inhibits IL-1β-induced NF-κB DNA binding in A549 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chew, E.-H., Lu, J., Bradshaw, T.D., et al. Thioredoxin reductase inhibition by antitumor quinols: A quinol pharmacophore effect correlating to antiproliferative activity. FASEB J. 22(6), 2072-2083 (2008).

    2. Callister, M.E., Pinhu, L., Catley, M.C., et al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br. J. Pharmacol. 155(5), 661-672 (2008).