A BKCa channel opener
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NS 11021

Item No. 15347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea
CAS Number
956014-19-0
Molecular Formula
C16H9BrF6N6S
Formula Weight
511.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mLDMF:PBS (pH 7.2)(1:3): 0.25 mg/mLDMSO: 10 mg/mLEthanol: 0.3 mg/mL
λmax
243, 288 nm
SMILES
S=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
InChi Code
InChI=1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
InChi Key
MDKAFDIKYQMOMF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).1 It is selective for BKCa and is thought to bind directly the ɑ subunit.1 NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bentzen, B.H., Nardi, A., Calloe, K., et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol. Pharmacol. 72(4), 1033-1044 (2007).

    2. Kun, A., Matchkov, V.V., Stankevicius, E., et al. NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats. Br. J. Pharmacol. 158(6), 1465-1476 (2009).