A selective inhibitor of PLD2
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ML-298

Item No. 15349

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide
CAS Number
1426916-02-0
Molecular Formula
C22H23F3N4O2
Formula Weight
432.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
203, 249 nm
SMILES
FC1=CC=C(C(NCCN2CCC3(C(NCN3C4=CC(F)=CC=C4)=O)CC2)=O)C=C1F
InChi Code
InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)
InChi Key
XAPVAKKLQGLNOY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM).1 It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 µM without inducing cytotoxicity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Reilly, M.C., Scott, S.A., Brown, K.A., et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J. Med. Chem. 56(6), 2695-2699 (2013).