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Diclofensine (hydrochloride)

Item No. 15355

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Ro 8-4650
Technical Information
Formal Name
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-isoquinoline, monohydrochloride
CAS Number
34041-84-4
Molecular Formula
C17H17Cl2NO • HCl
Formula Weight
358.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: 10 mg/ml
SMILES
CN(C1)CC(C2=CC=C(Cl)C(Cl)=C2)C3=C1C=C(OC)C=C3.Cl
InChi Code
InChI=1S/C17H17Cl2NO.ClH/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11;/h3-8,15H,9-10H2,1-2H3;1H
InChi Key
PEHOXCSPLOXNOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.1 While it has applications as an antidepressant, diclofensine increases locomotor activity, decreases food intake, and has abuse potential.2,3,4,5 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyttel, J., and Larsen, J.J. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J. Neurochem. 44(5), 1615-1622 (1985).

    2. Jackson, S.H., Turner, P., and Ehsanullah, R.S. A comparison of diclofensine and desmethylimipramine using tyramine pressor tests in normal subjects. Br. J. Clin. Pharmacol. 16(4), 427-429 (1983).

    3. Cilug, J., Ehsanullah, R.S., Hallett, C., et al. A clinical pharmacological comparison of diclofensine (Ro 8-4650) with nomifensine and amitriptyline in normal human volunteers. Br. J. Clin. Pharmacol. 15(5), 537-543 (1983).

    4. Lamb, R.J., and Griffiths, R.R. Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine. Psychopharmacology (Berl) 102(2), 183-190 (1990).

    5. Nakachi, N., Kiuchi, Y., Inagaki, M., et al. Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur. J. Pharmacol. 281(2), 195-203 (1995).