A peptide from the cell attachment site of fibronectin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

RGDS Peptide (trifluoroacetate salt)

Item No. 15359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginylglycyl-L-α-aspartyl-L-serine, trifluoroacetate salt
Synonyms
  • Fibronectin Inhibitor
  • H-Arg-Gly-Asp-Ser-OH
Molecular Formula
C15H27N7O8 • XCF3COOH
Formula Weight
433.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(O)=O)=O)CNC([C@@H](N)CCCNC(N)=N)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C15H27N7O8.C2HF3O2/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30;3-2(4,5)1(6)7/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19);(H,6,7)/t7-,8-,9-;/m0./s1
InChi Key
UMHUNRXMVGQLTE-YWUTZLAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $54

    Add

    10 mg

    $81

    Add

    25 mg

    $132

    Add

    50 mg

    $238

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen.1,2 RGDS interacts with α5β1 and αVβ3 integrins.3 This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).1,2 It also blocks the attachment of certain pathogens to cells.4,5 RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor (IC50 = ~10 μM).1,6,7 The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.8,9

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haverstick, D.M., Cowan, J.F., Yamada, K.M., et al. Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood 66(4), 946-952 (1985).

    2. Pierschbacher, M.D., and Ruoslahti, E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309(5963), 30-33 (1984).

    3. Basani, R.B., D'Andrea, G., Mitra, N., et al. RGD-containing peptides inhibit fibrinogen binding to platelet αIIbβ3 by inducing an allosteric change in the amino-terminal portion of αIIb. The Journal of Biological Chemisty 276(17), 13975-13981 (2014).

    4. Pottratz, S.T., and Martin, W.J., II Mechanism of Pneumocystis carinii attachment to cultured rat alveolar macrophages. J. Clin. Invest. 86(5), 1678-1683 (1990).

    5. Thomas, D.D., Baseman, J.B., and Alderete, J.F. Fibronectin tetrapeptide is target for syphilis spirochete cytadherence. J. Exp. Med. 162(5), 1715-1719 (1985).

    6. Gartner, T.K., and Bennett, J.S. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. The Journal of Biological Chemisty 260(22), 11891-11894 (1985).

    7. Ginsberg, M., Pierschbacher, M.D., Ruoslahti, E., et al. Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. The Journal of Biological Chemisty 260(7), 3931-3936 (1985).

    8. Dekkers, B.G.J., Bos, I.S.T., Gosens, R., et al. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am. J. Respir. Crit. Care Med. 181(6), 556-565 (2010).

    9. Moon, C., Han, J.R., Park, H.J., et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir. Res. 10(1), 18 (2009).