Prevents the synthesis of inducible heat shock proteins
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Heat Shock Protein Inhibitor I

Item No. 15395

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
CAS Number
218924-25-5
Synonyms
  • Hsp Inhibitor I
  • KNK 437
Molecular Formula
C13H11NO4
Formula Weight
245.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 10 mg/ml
λmax
253, 302, 338 nm
SMILES
O=C(N(C([H])=O)CC/1)C1=C\C2=CC=C(OCO3)C3=C2
InChi Code
InChI=1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2/b10-5+
InChi Key
LZGGUFLRKIMBDQ-BJMVGYQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Heat shock protein (Hsp) inhibitor I is a benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105, Hsp72, and Hsp40. At 100 μM, it can inhibit the development of thermotolerance in COLO 320 DM cells.1 Its effects on thermotolerance have been studied in the context of clinical fractionated hyperthermia as a modality of cancer therapy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yokota, S., Kitahara, M., and Nagata, K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res. 60(11), 2942-2948 (2000).

    2. Koishi, M., Yokota, S., Mae, T., et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin. Cancer Res. 7(1), 215-219 (2001).