Primes stem cells for differentiation
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Stem Cell Research
Differentiation

Stauprimide

Item No. 15398

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-benzamide
CAS Number
154589-96-5
Synonyms
  • N-Benzoyl-7-oxo Staurosporine
Molecular Formula
C35H28N4O5
Formula Weight
584.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 10 mg/mlEthanol: 0.2 mg/ml
λmax
239, 287, 317, 412 nm
SMILES
[H][C@]12N(C3=C4C5=C(C(NC5=O)=O)C6=C3N([C@](O2)(C)[C@H](OC)[C@H](N(C)C(C7=CC=CC=C7)=O)C1)C8=C6C=CC=C8)C9=C4C=CC=C9
InChi Code
InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1
InChi Key
MQCCJEYZKWZQHU-MPRCCEKMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $55

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    1 mg

    $94

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    5 mg

    $249

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    Product Description

    Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM).1 It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, S., Wurdak, H., Wang, J., et al. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell 4(5), 416-426 (2009).