A prodrug form of PSI-7411
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Labeled Version(s)
25045PSI-7977-13C-d3
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PSI-7977

Item No. 15402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester
CAS Number
1190307-88-0
Synonyms
  • GI-7977
  • Sofosbuvir
Molecular Formula
C22H29FN3O9P
Formula Weight
529.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
261 nm
SMILES
O=C(NC(C=C1)=O)N1[C@H]2[C@@](F)(C)[C@H](O)[C@@H](COP(N[C@@H](C)C(OC(C)C)=O)(OC3=CC=CC=C3)=O)O2
InChi Code
InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36?/m0/s1
InChi Key
TTZHDVOVKQGIBA-IAAJYNJHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    PSI-7977 is a prodrug form of the nucleoside analog and RNA-dependent RNA polymerase (RdRp) inhibitor PSI-7411.1 It is converted to PSI-7411 by cathepsin A and carboxylesterase 1 (CES1) via the intermediate PSI-352707. PSI-7977 inhibits hepatitis C virus (HCV) replication in an HCV replicon assay (EC50 = 0.092 µM). It also inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human brain cortical organoids derived from induced pluripotent stem cells (iPSCs) when used at a concentration of 20 µM.2 Formulations containing PSI-7977 have been used in the treatment of HCV infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murakami, E., Tolstykh, T., Bao, H., et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. The Journal of Biological Chemisty 285(45), 34337-34347 (2010).

    2. Mesci, P., de Souza, J.S., Martin-Sancho, L., et al. SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir. PLoS Biol. 20(11), e3001845 (2022).