A spin trap
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N-tert-butyl-α-Phenylnitrone

Item No. 15412

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-N-(phenylmethylene)-2-propanamine N-oxide
CAS Number
3376-24-7
Synonyms
  • PBN
Molecular Formula
C11H15NO
Formula Weight
177.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
226, 294 nm
SMILES
[O-]/[N+](C(C)(C)C)=C\C1=CC=CC=C1
InChi Code
InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChi Key
IYSYLWYGCWTJSG-XFXZXTDPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

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    Product Description

    N-tert-butyl-α-Phenylnitrone (PBN) is a cell permeable spin trap commonly used in free radical research.1 It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects.2 At millimolar concentrations, PBN has been shown to inhibit LPS-induced NF-κB DNA binding activity and inhibits COX-2 catalytic activity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haseloff, R.F., Mertsch, K., Rohde, E., et al. Cytotoxicity of spin trapping compounds. FEBS Lett. 418(1-2), 73-75 (1997).

    2. Floyd, R.A. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 222, 236-245 (1999).

    3. Kotake, Y., Sang, H., Miyajima, T., et al. Inhibition of NF-κB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN). Biochim. Biophys. Acta 1448, 77-84 (1998).