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Modafinil

Item No. 15417

Restricted Product (Schedule IV)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • CEP-1538
  • CRL 40476
  • (±)-Modafinil
Technical Information
Formal Name
2-[(diphenylmethyl)sulfinyl]-acetamide
CAS Number
68693-11-8
Molecular Formula
C15H15NO2S
Formula Weight
273.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.25 mg/mlMethanol: 1 mg/ml
SMILES
O=S(CC(N)=O)C(C1=CC=CC=C1)C2=CC=CC=C2
InChi Code
InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChi Key
YFGHCGITMMYXAQ-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
IV
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Modafinil (Item No. 15417) is an analytical reference standard that is classified as a nootropic. It is a wake-promoting agent that binds competitively and selectively to the dopamine transporter, modulating catecholaminergic signaling by inhibiting its activity (IC50 = 3 μM; Ki = 2 μM).1 With much weaker potency, modafinil can bind the norepinephrine transporter (IC50 < 10 μM) and the serotonin transporter (IC50 > 500 μM).2 Aside from its utility in sleeping disorders, modafinil has also been explored for treating the symptoms of fatigue that are often associated with multiple sclerosis (and other diseases) and as an intervention for cognitive impairments associated with drug addiction.3,4,5 Modafinil is regulated as a Schedule IV compound in the United States. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wisor, J. Modafinil as a catecholaminergic agent: Empirical evidence and unanswered questions. Front. Neurol. 4, 139 (2013).

    2. Minzenberg, M.J., and Carter, C.S. Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33(7), 1477-1502 (2008).

    3. Schwartz, J.R.L. Modafinil in the treatment of excessive sleepiness. Drug. Des. Devel. Ther. 2, 71-85 (2008).

    4. Campos, M.P., Hassan, B.J., Riechelmann, R., et al. Cancer-related fatigue: A review. Rev. Assoc. Med. Bras. 57(2), 211-219 (2011).

    5. Sofuoglu, M., DeVito, E.E., Waters, A.J., et al. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 64, 452-463 (2013).