A reversible purinergic P2Y12 receptor antagonist
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Labeled Version(s)
25027Ticagrelor-d7
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Ticagrelor

Item No. 15425

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
CAS Number
274693-27-5
Synonyms
  • AR-C 126532XX
  • AZD 6140
Molecular Formula
C23H28F2N6O4S
Formula Weight
522.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.15 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/ml
λmax
222, 255, 295 nm
SMILES
FC(C(F)=C1)=CC=C1[C@@H]2C[C@H]2NC3=C4C(N([C@@H]5C[C@H](OCCO)[C@@H](O)[C@H]5O)N=N4)=NC(SCCC)=N3
InChi Code
InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
InChi Key
OEKWJQXRCDYSHL-FNOIDJSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $55

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    25 mg

    $86

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    50 mg

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    Product Description

    Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.1,2 It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.3 Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zech, G., Hessler, G., Evers, A., et al. Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone. J. Med. Chem. 55(20), 8615-8629 (2012).

    2. Michelson, A.D. Advances in antiplatelet therapy. Hematology Am. Soc. Hematol. Educ. Program 2011(1), 62-69 (2011).

    3. Wallentin, L. P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use. Eur. Heart J. 30(16), 1964-1977 (2009).

    Product Citations

    Gasecka, A., Nieuwland, R., van der Pol, E., et al. P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets. Cardiol. J. 26(6), 782-789 (2019).