Pricing updated 2019-03-24. Prices are subject to change without notice.
Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).1 In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.2 Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
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1. Turpie, A.G.G. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases Arterioscler. Thromb. Vasc. Biol. 27(6), 1238-1247 (2007).
2. Lester, P.A., Coleman, D.M., Diaz, J.A., et al. Apixaban versus warfarin for mechanical heart valve thromboprophylaxis in a swine aortic heterotopic valve model Arterioscler. Thromb. Vasc. Biol. 37(5), 942-948 (2017).