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Apixaban

Item № 15427
CAS № 503612-47-3
Purity ≥98%
product image
                (CAS 503612-47-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $39.00 0.00
     5 mg $166.00 0.00
     10 mg $293.00 0.00
     50 mg $585.00 0.00

Pricing updated 2019-03-24. Prices are subject to change without notice.

Description
Synonyms
  • BMS 562247-01

Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).1 In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.2 Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.

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Technical Information
Formal Name
4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number
503612-47-3
Synonyms
  • BMS 562247-01
Molecular Formula
C25H25N5O4
Formula Weight
459.5
Purity
≥98%
Formulation
A crystalline solid
λmax
281 nm
SMILES
O=C1CCCCN1C2=CC=C(N3CCC(C(C(N)=O)=NN4C5=CC=C(OC)C=C5)=C4C3=O)C=C2
InChI Code
InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
InChI Key
QNZCBYKSOIHPEH-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Turpie, A.G.G. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases Arterioscler. Thromb. Vasc. Biol. 27(6), 1238-1247 (2007).

2. Lester, P.A., Coleman, D.M., Diaz, J.A., et al. Apixaban versus warfarin for mechanical heart valve thromboprophylaxis in a swine aortic heterotopic valve model Arterioscler. Thromb. Vasc. Biol. 37(5), 942-948 (2017).

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