A quorum-sensing signal peptide
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Extracellular Death Factor

Item No. 15478

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-asparagine
CAS Number
960129-66-2
Synonyms
  • EDF
Molecular Formula
C27H36N10O10
Formula Weight
660.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: SolubleWater: Soluble
SMILES
NC(C[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(N)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C27H36N10O10/c28-13(6-19(29)38)23(42)34-16(7-20(30)39)25(44)35-15(5-11-10-33-14-4-2-1-3-12(11)14)24(43)36-17(8-21(31)40)26(45)37-18(27(46)47)9-22(32)41/h1-4,10,13,15-18,33H,5-9,28H2,(H2,29,38)(H2,30,39)(H2,31,40)(H2,32,41)(H,34,42)(H,35,44)(
InChi Key
HMNOUINQUDZPAL-HILJTLORSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells.1 It is sensitive to extreme pH, high temperatures, and other stressful conditions.1 At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing population size in E. coli cultures.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolodkin-Gal, I., Hazan, R., Gaathon, A., et al. A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318(5850), 652-655 (2007).