Dual 5-LO/COX inhibitor
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BW 755C

Item No. 15490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
CAS Number
66000-40-6
Molecular Formula
C10H10F3N3
Formula Weight
229.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
286 nm
SMILES
NC(CC1)=NN1C2=CC=CC(C(F)(F)F)=C2
InChi Code
InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
InChi Key
CPXGGWXJNQSFEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $93

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    50 mg

    $376

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    100 mg

    $655

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    Product Description

    BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways, inhibiting 5-LO, COX-1, and COX-2 (IC50s = 0.75 μM, 0.65 μg/ml, and 1.2 μg/ml, respectively).1,2,3 It may also inhibit other LO pathways in vivo.4 Through these actions, BW 755C diminishes inflammation.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aizawa, Y., Kanai, T., Hasegawa, K., et al. Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. J. Med. Chem. 33(5), 1491-1496 (1990).

    2. Hlasta, D.J., Casey, F.B., Ferguson, E.W., et al. 5-Lipoxygenase inhibitors: The synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 34(5), 1560-1570 (1991).

    3. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90(24), 11693-11697 (1993).

    4. Tanaka, N., Espey, L.L., Kawano, T., et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am. J. Physiol. 260, E170-E174 (1991).

    5. Higgs, G.A., Flower, R.J., and Vane, J.R. A new approach to anti-inflammatory drugs. Biochem. Pharmacol. 28, 1959-1961 (1979).

    6. Calhoun, W., Yu, J., Sung, A., et al. Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. Agents Actions 27, 418-421 (1989).