A glomerular epithelial cell toxin
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Kidney & Renal Disease

Puromycin Aminonucleoside

Item No. 15509

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3'-amino-3'-deoxy-N,N-dimethyl-adenosine
CAS Number
58-60-6
Synonyms
  • NSC 3056
  • PANS
Molecular Formula
C12H18N6O3
Formula Weight
294.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
215, 275 nm
SMILES
O[C@H]([C@@H]1N)[C@@H](O[C@@H]1CO)N2C(N=CN=C3N(C)C)=C3N=C2
InChi Code
InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1
InChi Key
RYSMHWILUNYBFW-GRIPGOBMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $69

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    25 mg

    $157

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    50 mg

    $263

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    100 mg

    $493

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    Product Description

    Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.1 Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.2 When administered to rats at 0.5-5 μM, PANS affects glomerular epithelial cell adhesion, reducing α3β1 integrin expression.3 PANS also has been shown to decrease nephrin and podocin expression.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Azzam, M.E., and Algranati, I.D. Mechanism of puromycin action: Fate of ribosomes after release of nascent protein chains from polysomes. Proc. Natl. Acad. Sci. USA 70(12), 3866-3869 (1973).

    2. Furness, P.N., and Harris, K. An evaluation of experimental models of glomerulonephritis. Int. J. Exp. Pathol. 75(1), 9-22 (1994).

    3. Krishnamurti, U., Zhou, B., Fan, W.W., et al. Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells. J. Am. Soc. Nephrol. 12(4), 758-766 (2001).

    4. Guan, N., Ding, J., Deng, J., et al. Key molecular events in puromycin aminonucleoside nephrosis rats. Pathol. Int. 54(9), 703-711 (2004).