A PGF1α analog that inhibits gastric acid secretionand causes rat uterine contractions
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11-deoxy Prostaglandin F1α

Item No. 15512

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number
37785-98-1
Synonyms
  • 11-deoxy PGF1α
Molecular Formula
C20H36O4
Formula Weight
340.5
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >50 mg/mlDMSO: >50 mg/mlEthanol: >75 mg/mlPBS (pH 7.2): >2 mg/ml
SMILES
O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)CC1
InChi Code
InChI=1S/C20H36O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-19,21-22H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+,19-/m0/s1
InChi Key
HYBPXYQCXNOTFK-DUSCRHDRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%.1 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α.2 It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lippmann, W. Inhibition of gastric acid secretion in the rat by synthetic prostaglandins. J. Pharm. Pharmacol. 21(5), 335-336 (1969).

    2. Broughton, B.J., Caton, M.P.L., Christmas, A.J., et al. Uterine stimulant action of some ω-chain modified (±)-11-deoxyprostaglandins. Prostaglandins 22(1), 53-64 (1981).

    3. Hall, D.W.R., and Jaitly, K.D. Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins 11(3), 573-587 (1976).