A potent, selective 5-HT3 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ramosetron (hydrochloride)

Item No. 15548

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-methanone, monohydrochloride
CAS Number
132907-72-3
Molecular Formula
C17H17N3O • HCl
Formula Weight
315.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
212, 244, 306 nm
SMILES
O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H]3CCC4=C(NC=N4)C3.Cl
InChi Code
InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
InChi Key
XIXYTCLDXQRHJO-RFVHGSKJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $75

    Add

    25 mg

    $168

    Add

    50 mg

    $315

    Add

    100 mg

    $589

    Add
    Product Description

    Ramosetron is a potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM).1,2 It has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors.1 Ramosetron competitively blocks serotonin-mediated contraction of the colon.1 It has applications in ameliorating diarrhea-predominant inflammatory bowel syndrome and postoperative nausea and vomiting.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miyata, K., Kamato, T., Nishida, A., et al. Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]- 4,5,6,7-tetrahydro-1H-benzimidazol hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue. J. Pharmacol. Exp. Ther. 259(1), 15-21 (1991).

    2. Manning, D.D., Cioffi, C.L., Usyatinsky, A., et al. Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome. Bioorg. Med. Chem. Lett. 21(1), 58-61 (2011).

    3. Manabe, N., Rao, A.S., Wong, B.S., et al. Emerging pharmacologic therapies for irritable bowel syndrome. Curr. Gastroenterol. Rep. 12(5), 408-416 (2010).

    4. Mihara, T., Tojo, K., Uchimoto, K., et al. Reevaluation of the effectiveness of ramosetron for preventing postoperative nausea and vomiting: A systematic review and meta-analysis. Anesth. Analg. 117(2), 329-339 (2013).