An Omi/HtrA2 protease inhibitor
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UCF 101

Item No. 15550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
CAS Number
313649-08-0
Molecular Formula
C27H17N3O5S
Formula Weight
495.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 5 mg/ml
λmax
430 nm
SMILES
S=C(N(C1=CC=CC=C1)C(/C2=C\C3=CC=C(C4=CC=CC=C4[N+]([O-])=O)O3)=O)N(C5=CC=CC=C5)C2=O
InChi Code
InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
InChi Key
NVNSXBXKNMWKEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $86

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    10 mg

    $152

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    25 mg

    $329

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    Product Description

    UCF 101 is an inhibitor of the proteolytic activity of Omi/HtrA2 (IC50 = 9.5 μM).1 It is highly specific for Omi/HtrA2, demonstrating less potent activity when tested against a panel of various other serine proteases (IC50s range from 200 to >500 μM).1 Additionally, UCF 101 is naturally fluorescent, thus enabling the visualization of its entry into cells.1 UCF 101 has been used to decrease cerebral infarct size in a rat model of cerebral ischemia, demonstrating neuroprotective effects by reducing apoptosis of cortical cells.2 It has also been reported to be protective of cardiomyocytes against ischemic injury through a mechanism that prevents Omi/HtrA2 proteolysis of Thanatos-associated protein 5, a cardiac-specific nuclear protein that controls cell cycle progression.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cilenti, L., Lee, Y., Hess, S., et al. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. The Journal of Biological Chemisty 278(13), 11489-11494 (2003).

    2. Su, D., Su, Z., Wang, J., et al. UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats. Anat. Rec. (Hoboken) 292(6), 854-861 (2009).

    3. Balakrishnan, M.P., Cilenti, L., Mashak, Z., et al. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. Am. J. Physiol. Heart Circ. Physiol. 297(2), H643-H653 (2009).