A PKA substrate
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Kemptide

Item No. 15555

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-glycine
CAS Number
65189-71-1
Synonyms
  • NSC 332190
Molecular Formula
C32H61N13O9
Formula Weight
771.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(CNC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](N)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C32H61N13O9/c1-16(2)12-19(33)26(50)42-21(9-7-11-39-32(36)37)29(53)43-20(8-6-10-38-31(34)35)28(52)41-18(5)25(49)45-23(15-46)30(54)44-22(13-17(3)4)27(51)40-14-24(47)48/h16-23,46H,6-15,33H2,1-5H3,(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,44,54)(H,45,49)(H,47,48)(H4,34,35,38)(H4,36,37,39)/t18-,19-,20-,21-,22-,23-/m0/s1
InChi Key
WIGDGIGALMYEBW-LLINQDLYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    10 mg

    $283

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    25 mg

    $645

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    Product Description

    Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA) as it carries the recognition and phosphorylation site of PKA.1 Various cultured cells can catalyze the phosphorylation of kemptide in the presence of extracellular ATP and cAMP (Kms = 3-4 μM) with plasma membranes remaining intact.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kübler, D., Pyerin, W., Bill, O., et al. Evidence for ecto-protein kinase activity that phosphorylates kemptide in a cyclic AMP-dependent mode. The Journal of Biological Chemisty 264(24), 14549-14555 (1989).