A bioavailable agonist of RORα
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Neoruscogenin

Item No. 15567

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
spirosta-5,25(27)-diene-1β,3β-diol
CAS Number
17676-33-4
Synonyms
  • 25(27)-Dehydroruscogenin
Molecular Formula
C27H40O4
Formula Weight
428.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
C=C(CO1)CC[C@@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChi Code
InChI=1S/C27H40O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,16,18-24,28-29H,1,6-14H2,2-4H3/t16-,18+,19+,20-,21-,22-,23+,24-,25-,26-,27+/m0/s1
InChi Key
ALTRINCJVPIQNK-NHIXJPGBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $132

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    5 mg

    $525

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    10 mg

    $918

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    Product Description

    Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.1 It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM).2 In mice, neoruscogenin up-regulates the expression of several RORα-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barbic, M., Willer, E.A., Rothenhöfer, M., et al. Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. Phytochemistry 90, 106-113 (2013).

    2. Helleboid, S., Haug, C., Lamottke, K., et al. The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1). J. Biomol. Screen. 19(3), 399-406 (2014).