A fluorescent marker for autophagic vacuoles
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Monodansylcadaverine

Item No. 15571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide
CAS Number
10121-91-2
Synonyms
  • Dansylcadaverine
  • MDC
Molecular Formula
C17H25N3O2S
Formula Weight
335.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: 10 mg/ml
SMILES
CN(C)C1=C(C=CC=C2S(NCCCCCN)(=O)=O)C2=CC=C1
InChi Code
InChI=1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChi Key
MLEBFEHOJICQQS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $32

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    250 mg

    $64

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    500 mg

    $119

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    1 g

    $220

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    Product Description

    Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles.1,2 It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments.1 MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niemann, A., Takatsuki, A., and Elsässer, H.P. The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe. J. Histochem. Cytochem. 48(2), 251-258 (2000).

    2. Biederbick, A., Kern, H.F., and Elsässer, H.P. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur. J. Cell Biol. 66(1), 3-14 (1995).