An activator of P2X purinergic receptors
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BzATP (triethylammonium salt)

Item No. 15577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adenosine 5′-(tetrahydrogen triphosphate), 3′-(4-benzoylbenzoate), compd. with N,N-diethylethanamine (1:1)
Molecular Formula
C24H24N5O15P3 • C6H15N
Formula Weight
816.6
Purity
≥75% (mixture of regioisomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 14 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
257 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O.CCN(CC)CC
InChi Code
InChI=1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35);4-6H2,1-3H3/t16-,19-,20-,23-;/m1./s1
InChi Key
HVOVBTNCGADRTH-WBLDMZOZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    Product Description

    The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP (ammonium salt) is an activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP.1,2,3 It activates the human, rat, and mouse receptors with EC50 values of 0.7, 3.6, and 285 μM, respectively.4 BzATP is not selective for P2X7 as it can potently activate other P2X receptors, but without the marked superiority to ATP as an agonist.1,2,5 BzATP can also be used as a photoaffinity probe to study adenine nucleotide binding to ATPases.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anderson, C.M., and Nedergaard, M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends Neurosci. 29(5), 257-262 (2006).

    2. Bianchi, B.R., Lynch, K.J., Touma, E., et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 376(1-2), 127-138 (1999).

    3. Michel, A.D., Xing, M., and Humphrey, P.P. Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X7 receptors. Br. J. Pharmacol. 132(7), 1501-1508 (2001).

    4. Young, M.T., Pelegrin, P., and Surprenant, A. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol. Pharmacol. 71(1), 92-100 (2007).

    5. Zhong, Y., Dunn, P.M., Xiang, Z., et al. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br. J. Pharmacol. 125(4), 771-781 (1998).

    6. Williams, N., and Coleman, P.S. Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. The Journal of Biological Chemisty 257(6), 2834-2841 (1982).