A β-adrenergic receptor agonist
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Dobutamine (hydrochloride)

Item No. 15582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol, monohydrochloride
CAS Number
49745-95-1
Synonyms
  • Dobutrex
  • Inotrex
  • NSC 299583
Molecular Formula
C18H23NO3 • HCl
Formula Weight
337.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2); (1:7): 0.1 mg/mlDMSO: 12 mg/mlEthanol: 1 mg/ml
λmax
225, 280 nm
SMILES
OC1=CC=C(CCC(C)NCCC2=CC(O)=C(O)C=C2)C=C1.Cl
InChi Code
InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChi Key
BQKADKWNRWCIJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $29

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    10 mg

    $51

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    50 mg

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    100 mg

    $113

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    Product Description

    Dobutamine is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo.1,2,3 It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions.1,2 As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects.1 Dobutamine is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tuttle, R.R., and Mills, J. Dobutamine: Development of a new catecholamine to selectively increase cardiac contractility. Circ. Res. 36(1), 185-196 (1975).

    2. Deighton, N.M., Motomura, A., Bals, S., et al. Characterization of theβadrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium. J. Pharmacol. Exp. Ther. 262(2), 532-538 (1992).

    3. Brown, L., Näbauer, M., and Erdmann, E. Dobutamine: Positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn Schmiedebergs Arch. Pharmacol. 335(4), 385-390 (1987).

    4. Innocenti, A., Gülçin, I., Scozzafava, A., et al. Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg. Med. Chem. Lett. 20(17), 5050-5053 (2010).