A metabolite of ethanol that targets dopaminergic neurons
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(±)-Salsolinol (hydrochloride)

Item No. 15597

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-1-methyl-6,7-isoquinolinediol, monohydrochloride
CAS Number
79923-51-6
Molecular Formula
C10H13NO2 • HCl
Formula Weight
215.7
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleWater: soluble
λmax
288 nm
SMILES
CC1NCCC2=C1C=C(O)C(O)=C2.Cl
InChi Code
InChI=1S/C10H13NO2.ClH/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6;/h4-6,11-13H,2-3H2,1H3;1H
InChi Key
WSVCGYSRZYNJMC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $54

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    500 mg

    $250

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    Product Description

    (±)-Salsolinol is a metabolite of ethanol produced by the condensation of dopamine with acetaldehyde in the brain. It is thought to contribute to some aspects of alcohol’s addictive properties in part through its ability to stimulate dopamineric neurons in the posterior ventral tegmental area of the brain.1 At 0.1 μM, (±)-salsolinol has been shown to: a) depolarize dopamineric neurons, which increases their firing rate; b) activate μ-opioid receptors on GABAergic neurons, which disinhibits dopamineric neurons; and c) activate dopamine1-like receptors, which enhances pre-synaptic glutamate transmission to dopamineric neurons.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, G., Krnjevic, K., and Ye, J.H. Salsolinol modulation of dopamine neurons. Front. Behav. Neurosci. 7(52), (2013).