A selective δ-opioid receptor agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SNC 80

Item No. 15599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide
CAS Number
156727-74-1
Synonyms
  • NIH 10815
Molecular Formula
C28H39N3O2
Formula Weight
449.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.1 mg/mlDMSO: 0.1 mg/ml
SMILES
O=C(N(CC)CC)C(C=C1)=CC=C1[C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3
InChi Code
InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
InChi Key
KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    25 mg

    $315

    Add
    Product Description

    SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor.1,2,3 It effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers.4 SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.1,2,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bilsky, E.J., Calderon, S.N., Wang, T., et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J. Pharmacol. Exp. Ther. 273(1), 359-366 (1995).

    2. Calderon, S.N., Rothman, R.B., Porreca, F., et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective, nonpeptide δ opioid receptor agonist. J. Med. Chem. 37(14), 2125-2128 (1994).

    3. Knapp, R.J., Santoro, G., De Leon, I.A., et al. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J. Pharmacol. Exp. Ther. 277(3), 1284-1291 (1996).

    4. Metcalf, M.D., Yekkirala, A.S., Powers, M.D., et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem. Neurosci. 3(7), 505-509 (2012).

    5. Danielsson, I., Gasior, M., Stevenson, G.W., et al. Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. Pharmacol. Biochem. Behav. 85(2), 428-434 (2006).

    Product Citations

    Berardinelli, D., Taoussi, O., Ovat, D.Y., et al. Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. Arch. Toxicol. (2025).