A peroxiredoxin inhibitor
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Conoidin A

Item No. 15605

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide
CAS Number
18080-67-6
Molecular Formula
C10H8Br2N2O2
Formula Weight
348.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
240, 278, 391 nm
SMILES
[O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=C1C=CC=C2
InChi Code
InChI=1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2
InChi Key
DQKNFTLRMZOAMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $63

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    50 mg

    $94

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    100 mg

    $123

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    250 mg

    $274

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    Product Description

    Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and act in redox signaling pathways. Increased expression of human peroxiredoxin is associated with cancer, cardiovascular dysfunction, and neurodegeneration. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme.1,2 It has been shown to inhibit peroxiredoxin II (IC50 = 23 µM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum.1,2,3 At 5 µM, conoidin A can also inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II, but not peroxiredoxin III.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haraldsen, J.D., Liu, G., Botting, C.H., et al. Identification of conoidin A as a covalent inhibitor of peroxiredoxin II. Org. Biomol. Chem. 7, 3040-3048 (2009).

    2. Nguyen, J.B., Pool, C.D., Wong, C.Y., et al. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem. Biol. 20(8), 991-1001 (2013).

    3. Liu, G., Botting, C.H., Evans, K.M., et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem 5(1), 41-45 (2010).