A selective inhibitor of the mitochondrial sodium-calcium exchanger NCLX
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CGP 37157

Item No. 15611

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
CAS Number
75450-34-9
Molecular Formula
C15H11Cl2NOS
Formula Weight
324.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mM
λmax
213, 245 nm
SMILES
O=C1CSC(C2=CC=CC=C2Cl)C3=CC(Cl)=CC=C3N1
InChi Code
InChI=1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
InChi Key
KQEPIRKXSUIUTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    25 mg

    $203

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    50 mg

    $378

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    Product Description

    CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 μM in isolated mitochondria).1 It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum.1 CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis.2,3 CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 μM).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cox, D.A., Conforti, L., Sperelakis, N., et al. Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J. Biomed. Sci. 21(4), 595-599 (1993).

    2. Baron, K.T., and Thayer, S.A. CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur. J. Pharmacol. 340(2-3), 295-300 (1997).

    3. White, R.J., and Reynolds, I.J. Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. J. Physiol. 498(Pt 1), 31-47 (1997).

    4. Palty, R., Silverman, W.F., Hershfinkel, M., et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc. Natl. Acad. Sci. USA 107(1), 436-441 (2010).

    5. Parnis, J., Montana, V., Delgado-Martinez, I., et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. J. Neurosci. 33(17), 7206-7219 (2013).